Biochem/physiol Actions

Sultopride is an orally active benzamide class dopamine receptor D2/3-selective antagonist (K_i = 18 nM/rat D2, 22 nM/human D3, 7.7 µM/human D4, >10 µM/rat D1 by competitive binding against 0.5 nM Spiperone, 0.2 nM YM-09151-2, 5 nM Spiperone, 0.2 nM SCH23390 for respective receptor) that displays in vivo antipsychotic efficacy with moderate atypical index. Sultopride exhibits little or no affinity toward 5-HT1A2/33, adrenaline receptor α₁/α₂, Ach receptor, histamine receptor H1, or Sigma receptors σ₁/σ₂. Sultopride is a racemic material composed of the highly active (-) and the less potent (+) enenatiomers.